Position : Major Tasks Develop implement and apply new alternative methodologies (NAMs) in the context of the new toxicity testing paradigm based on more cell-based assays and a comprehensive mechanistic understanding of cause- consequence relationships for adverse effects induced by (agro) chemicals. * Define and shape new in vitro methodologies and innovative approaches (NAMs) for Next Generation Risk Assessment of plant protection products * Design, develop, and implement complex in vitro assays (CIVM) to predict potential adverse effects in humans * Establish toxicology and business relevant medium- to high- throughput in vitro test systems able to mimic the in vivo situation in order to quantify the risk in human beings * Utilize advanced technologies to study biological and molecular processes : e.g., apply relevant biomarkers and use image analysis for quantification, perform biological assays to monitor cell behavior and function * Review appropriate literature pertaining to current or proposed projects * Independently plan, analyze, interpret data, set-up critical path and path-forward * Communicate and report study findings, results, analyses, and future direction to project partners (to direct manager & collaborators) * Actively work with experienced Research Toxicologists to set up experiments and drive data analysis and interpretation * Participate in project meetings and contribute to scientific exchange with internal and external scientific communities Position : Skills... Education : * Biologist or Scientist with a PhD degree related to tissue engineering, biotechnology, systems biology, toxicology, or related disciplines. Skills : * 2 years of experience in academic, pharmaceutical, or biotechnology settings * Hands-on experience with a variety of cell-based models and experience with different readouts along with state-of-the-art of imaging methods b * Experience in differentreadouts along with state-of-the-art of imaging methods and molecular biology (immunostaining, confocal imaging, qPCR, flow cytometry, toxicogenomics etc * Expertise in toxicity assays with hepatocytes/neurons and/or experimental characterization * Experience in mathematically description of dose/concentration toxicity pathways would BE a plus * Demonstrated experience with global multi-disciplinary teams * Accurate and precise worker with strong analytical and problem- solvingskills (creative, critical, out-of-the-box thinker) * Strong personal organization skills are required * Fluent verbal and written communication skills in English, basic knowledge of French is an advantage * Team player with the ability to work independently to drive projects
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